An In-vitro Study of the Effect of Hydroethanol Extract of Annona senegalensis Leaves on Bitis rhinoceros (Viperidae) Venom Induced Coagulopathy

Bites of Bitis Rhinoceros (Viperidae) usually cause a hemorrhagic syndrome in the victims. This is medical emergency. Antivenom immunotherapy remains effective. However, its availability and cost still limiting use Africa general Côte d'Ivoire particularly. The roots plant Annonaceae family (Annona senegalensis) are used to treat cases envenomations by Viperidae. objective this work study modulation effect rhinoceros venom on coagulation parameters hydroethanol extract Annona senegalensis leaves.
 phytochemical was carried out monitoring three blood (PT, APTT, Fibrinogen) from healthy individuals presence absence hydro-ethanolic extract. Phytochemistry revealed saponins, tannins, polyphenolic compounds including flavonoids plant.
 showed that at concentration 10-2 mg/mL modifies some decrease half prothrombin rate, increase time. It has no fibrinogen level.
 inhibited 1 leaves contain molecules could neutralize action disorder.